Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats.

Reproductive and developmental disorders are the most sensitive toxic effects caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD is thought to produce many, if not all, of these toxic effects by impairing steroidogenesis and/or steroid action during the prenatal or early postnatal stages. Continue Reading

2015.01.09 I.O.M Report: Post-Vietnam Dioxin Exposure in Agent Orange–Contaminated C-123 Aircraft

Between 1972 and 1982, approximately 1,500 to 2,100 U.S. Air Force (AF) Reserve personnel trained and worked on C-123 aircraft that previously had been used to spray herbicides, including Agent Orange (AO), during Operation Ranch Hand (ORH) in the Vietnam War. Samples taken from these aircraft show the presence of AO residues. Continue Reading

2008.03.05 I.O.M Report: The Utility of Proximity-Based Herbicide Exposure Assessment in Epidemiologic Studies of Vietnam Veterans

A new Institute of Medicine report, The Utility of Proximity-Based Herbicide Exposure Assessment in Epidemiologic Studies of Vietnam Veterans, presents the conclusions and recommendations of a committee that was convened to provide guidance to the Department of Veterans Affairs about the best use of an exposure assessment model that was developed to address this problem. Continue Reading